San Francisco 49ers Odds, Moneylines, Spreads and Futures Markets
The San Francisco 49ers odds outlook differs from where it stood in January. The 49ers were two wins from the Super Bowl before Seattle routed them in the divisional round.
San Francisco finished 12-5 in 2025 and upset the defending champion Eagles 23-19 in the wild card round. The run lasted just one more week, though, as Seattle rolled to a 41-6 win in the divisional round before going on to win the Super Bowl.
Injuries were a major part of San Francisco’s 2025 story, and they still matter when looking at this year’s odds. Nick Bosa missed the season after tearing his ACL in Week 3, and is now dealing with tendinitis in the repaired knee. Fred Warner, who fractured and dislocated his ankle in October, is healthy again for 2026, while George Kittle was activated from the PUP list after his Achilles injury.
The coaching staff has changed, too. Robert Saleh left in January to become Tennessee’s head coach, with Kyle Shanahan bringing in former Falcons head coach Raheem Morris to run the defense. Through it all, Christian McCaffrey won Comeback Player of the Year.
If you’re new to betting, our NFL betting apps guide ranks the sportsbooks that are worth downloading before kickoff. This page covers Super Bowl, playoff, and division prices, betting explainers, and prop examples for the season ahead.
San Francisco 49ers Odds This Week
San Francisco 49ers Odds to Win Super Bowl 61
Eight trips to the Super Bowl, five championships, and the most recent one still stings the worst. San Francisco’s biggest lead in Super Bowl LVIII was seven points, 10-3 in the second quarter, before Kansas City rallied to force overtime at 19-19 and won it 25-22 back in February 2024. The 49ers haven’t been back since, and this year’s injury-racked roster isn’t gaining much respect from oddsmakers.
DraftKings lists San Francisco at +1900 to win it all, while BetMGM is a touch friendlier at +1700. That places the San Francisco 49ers odds to win Super Bowl 61 in the second tier of contenders: not hopeless, but not a true favorite either. Our full Super Bowl odds board shows how far back that number sits from the top of the market.
| Sportsbook | Super Bowl 61 Odds |
|---|---|
| DraftKings | +1900 |
| BetMGM | +1700 |
Check our BetMGM review.
San Francisco 49ers Odds to Make Playoffs
The playoff market tells a different story. San Francisco isn’t being priced like a team fighting to sneak into the postseason. BetMGM has the 49ers at -150 to make the playoffs and +125 to miss them. That’s a fairly positive outlook after last year’s divisional-round exit, although the NFC West gives them little room for error.
San Francisco 49ers odds to make playoffs reflect a healthier roster, with Warner back and Bosa and Kittle working their way back from injuries. To see how that number compares across the conference, check our NFL playoff odds page for more details.
| Sportsbook | To Make Playoffs | To Miss Playoffs |
|---|---|---|
| BetMGM | -150 | +125 |
San Francisco 49ers Odds to Win Division
Nobody in the NFC West has won more division titles than San Francisco. The 49ers have claimed the crown 22 times, with six of those coming since the division was realigned in 2002. Their most recent title came in 2023, a 12-5 season that carried all the way to Super Bowl LVIII. Seattle won the division last season.
San Francisco 49ers odds to win the division sit behind both the Rams and the Seahawks this year. BetMGM has Los Angeles as the favorite at -105, with Seattle next at +210 and San Francisco further back at +325. Every team in the division, along with San Francisco’s number, is tracked on our NFC West odds page.
| Sportsbook | NFC West Odds |
|---|---|
| BetMGM | +325 |
The win-total market points in the same direction. It’s set at 10.5 for 2026, with the Over priced at +115 and the Under at -140, and it’s tracked the same way as every other team’s on our NFL win totals page.
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More San Francisco 49ers Betting Markets
Once you get to the individual games, the San Francisco 49ers betting odds are straightforward: moneyline, spread, total, and player props.
San Francisco 49ers Moneylines
San Francisco 49ers odds this week open with the moneyline, the simplest bet in football: pick who wins. For Week 1 in Los Angeles, FanDuel has the Rams at -200 favorites, with San Francisco at +168.
A $100 bet at that underdog price wins $168 if the 49ers pull it off, for a $268 total payout. Our full NFL odds board carries the same moneyline format for all 32 teams.
San Francisco 49ers Spreads
The Rams are 3.5-point favorites over San Francisco in that Week 1 matchup, meaning Niners bettors get 3.5 points added to the final score. A San Francisco bet at +3.5 wins if the 49ers win outright, or lose by three points or less.
FanDuel prices the 49ers side at -105, so a $105 wager nets $100 in profit if the number holds. Lines tend to shift as the week goes on, and a new sign-up can often lock in extra value through the latest NFL betting promos before it settles.
San Francisco 49ers Totals (Over/Under)
Totals ignore the winner and focus only on the combined score. Sportsbooks have the 49ers-Rams total sitting at 48.5 points for Week 1, and betting the Over means rooting for both teams to move the ball, not just one.
A $100 bet at the standard -110 price profits $90.91 if the two clubs combine for 49 points or more. Elsewhere on the board, nobody on San Francisco’s roster is close to the front of the NFL MVP odds race.
San Francisco 49ers Props
McCaffrey is one of the main names to watch in San Francisco's player-prop market after his Comeback Player of the Year season. His season rushing touchdown total is set at 8.5, priced at -115 on the Over and -110 on the Under.
A $115 bet on the Over returns $100 in profit if McCaffrey finds paydirt nine or more times on the ground in 2026. Before placing anything on markets like these, our rankings of the best NFL betting sites break down which sportsbooks offer the deepest prop menus and the best limits.
San Francisco 49ers Prediction Markets
Kalshi and Polymarket work differently from traditional sportsbooks. Instead of placing bets with odds determined by the house, traders freely buy and sell event contracts. These are always priced between $0.01 and $0.99, which also reflects the market’s implied probability of the outcome occurring.
For example, a contract trading at $0.30 means the market believes there’s a 30% chance of the outcome occurring. Once the event is finished, contracts that correctly predicted the outcome are settled at $1, while wrong predictions settle at $0.
San Francisco’s championship event contracts have traded around $0.05 on Kalshi and closer to $0.04 on Polymarket. Buying 1,000 of those shares for roughly $50 would turn into $1,000 if the 49ers somehow win it all, a $950 profit, though a loss means the position expires worthless.
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- High-quality iOS and Android apps
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- Variety of bonuses and ongoing promos
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San Francisco 49ers Odds FAQ
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